Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)
نویسندگان
چکیده
منابع مشابه
Symptomatic therapy of Duchenne Muscular Dystrophy (DMD)
DMD certainly has a remarkable position amongst all hereditary muscle disorders. Noteworthy is its relatively high incidence as a " rare disease " , its X-chromosomal mode of inheritance, the high frequency of new mutations , as well as its relatively rapid and fatal course. For a century the disorder was considered to be untreatable. Only 40 years ago the patients' " natural " age at death was...
متن کاملTransition from childhood to adulthood in Duchenne muscular dystrophy (DMD)
Duchenne muscular dystrophy (DMD) is the most common childhood muscular dystrophy, affecting 1 in 3500 live male births. Mutations in the X chromosome result in an absence of dystrophin, causing progressive muscle degeneration and loss of ambulation by the early teens with respiratory, orthopaedic and cardiac complications. Without intervention these complications lead to death at a mean age of...
متن کاملDuchenne Muscular Dystrophy (DMD) Protein-Protein Interaction Mapping
Objective Duchenne muscular dystrophy (DMD) is one of the mortal diseases, subjected to study in terms of molecular investigation. In this study, the protein interaction map of this muscle-wasting condition was generated to gain a better knowledge of interactome profile of DMD. Materials & Methods Applying Cytoscape and String Database, the protein-protein interaction network was constructed ...
متن کاملMitochondrial Dysfunction in Duchenne Muscular Dystrophy
Muscular Dystrophy (MD) is an X-linked recessive disease affecting mainly boys at a rate of 1 in every 3500 live births. The most common and severe form of the disease is Duchenne Muscular Dystrophy (DMD). The disease is characterized by a relatively rapid wasting of skeletal muscle tissue to a point that leads to paralysis in all patients that suffer from the disease. Unfortunately, due to res...
متن کاملIntegrated Treatment Regime for Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is the most common hereditary neuromuscular disease affecting all races and ethnic groups, with a sex linked inheritance pattern of 1 in 3500 male births. The underlying genetic defect results in the loss of a structural protein called dystrophin that normally serves to provide mechanical stability during muscle contraction. As a result of this loss, there is e...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2018
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.8b00287